In theory it seems doable to hitchhike directly from the center, as there is the entrance to several motorways. However, the people of the city are not very hitchhike-friendly, so it is better to directly go to a petrol station on the motorway.
It should be noted that there is barely any traffic around and out of the city on Sunday mornings. This may be the case with other parts of France.
<map lat='48.55388717497782' lng='7.7474212646484375' zoom='11' view='0' float='right' height='400'/> Public transport is very cheap for a western European city. A 24 hour pass costs EUR 4.30, for EUR 6.40 you get a 24 hour pass for 3 persons (August 2015). See fares.
Going east (Germany)
Walking (from Strasbourg centre) to Kehl takes about 50 minutes if you go the shortest route (check google maps!).
Alternatively, you can take the regional train (around 6 minutes for about EUR 3) or the bus (line #21; one bus every 30 min; EUR 1.30; takes longer than the train). The bus stops in several places from "Ancienne Douanne" (in the centre) through to the east side of the city. On Sunday the first bus leaves at 9:30 am.
By train, for 2 euro more, you can continue after Kehl till Appenweier. From there you can walk or hitchhike to the petrol station "Rasthof Renchtal" (2,5 km check the route on maps.google.com or see Renchtal for details ). It can be a good alternative to Kehl because in 30 minutes more, you're on the German motorway network.
Going North (Metz, Saarbrücken) and South (Mulhouse, Switzerland)
Take the tram (red line) to Illkirch Lixenbuhl and then the bus (line 2) to Ostwald Eglise. From the bus stop, with your back to the church, turn right and walk down the road towards the big house around some green fields at the junction.You then turn right and you keep walking up this road parallel to the the Nachtweid forest.
A small road runs along its edge and leads to the first petrol station on the A35 motorway. This is for traffic going south towards Mulhouse and Switzerland.
Across from this is the second petrol station for the north (Metz, Saarbrucken, etc). You can access this from a muddy path beside the bridge.
In September 2013 I took the bus to Ostwald Eglise. If you face the church, just follow the road parallel left of the church. This road leads to a bridge. You will reach the bridge in 10 minutes of walking. If you want to go to Switserland, DON'T cross the bridge. Just before crossing the bridge, there is a narrow steeple path going down on your left side. This path leads to the station. You will find it in 2 minutes walking. All the best, Robbel
Going North (Metz, Saarbrücken, Paris)
Take a regional train direction Brumath/Mommenheim and make sure it stops at Stephansfeld. From there you can walk within 15 min to the gas station Aer de Seervice Brumath on the A4 and start hitchhiking straight at the gas station. The trainticket from Strasbourg to Stephansfeld costs EUR 3.50 (2011).
Alternatively, just walk (10 minutes from the centre) to Place de Huguenau, and walk to the entrance of the A4 (there is a cycle path that leads right next to it if you don't like contending with the cars). There is a lot of space for people to stop and it is the best way to head north from the centre.
- Join the A4 by the "going north route" (see upper). Good solution for Paris.
- Join the N4: take the "bus interurbain" #205,#206 or #207 from "Ancienne synagogue-Les Halles" or "Gare Centrale" to Ittenheim (1,80 euros). From Ittenheim's bus stop, walk till the entry of the village (3 minutes), and you're on the best spot of the N4 to leave Strasbourg. This road has the advantage to be free of fees so many cool people use it. I recommend it to go to Metz and Nancy cause you don't loose a lot of time compared to motorways and you have many more chances to get a lift. Very efficient, I never waited more than 5 minutes there!