Santa Cruz
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Santa Cruz in California is a great place to hitchhike. Many people hitchhike locally and it's on the I-1 and close to the I-101, some of the best highways for hitchhiking.
Going South to Los Angeles
If you're not in a hurry, take the I-1. Other the I-101 is probably your best bet.
If you try to go to the I-5, be aware that the I-152 and the I-5 intersection is just highways. Don't even try to wait there for a ride. It's better to start walking down South and hope to get picked up by a friendly soul coming down from Bay Area.