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Therefore, if you don't get a ride you wanted, ask driver to take you to a motorway toll ramps next to hotel Nais ("naplatna rampa Nais - Niš"). All vehicles need to pass there no matter how much they are going to use a motorway. It's only 5km away from your standpoint. Once on Nais tolls, getting a ride is fairly easy, and you'll be sure that you're hitchhiking 100% of the traffic that goes north via this motorway.

Take bus 10 from the central square (the bus stop is next to McDonalds). Get off at the last stop, in a suburban area called Novo Selo (sometimes also referenced as "naselje 9. maj"). The bus ride should cost around 50 RSD. Walk further in the same direction and cross a bridge over the motorway. You can hitch from after the bridge.