=== East towards [[Mobile]] ===
Take either the 62 or the 64 bus to where Bullard avenue meets interstate 10 (get off at the McDonaldMcD's). On the south side of the interstate there's a nice long on-ramp with plenty of cars going not too fast, and space for them to pull over (a hard shoulder).
Once out of the city, it's a good idea to stop at the I-10/US-190 junction in Slidell. There is a large truck stop there and plenty of rides across the country.