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if you enter mexico that way ask to be dropped at a metro station. most probably you will pass the station "blvd puerto aereo" while entering the city.

You can take the autopista or the beautiful carretera a cuernavace, if you leave the city via carretera you can (if the weather is fine) overlook the whole city.

both roads begin at the end of tlalpan. one way to get there is from metrobus last station "doctor galvez". the metrobus runs down the long norht south road "insurgents", you need a card (minimum 100 pesos) to take the metrobus, but if you ask people will let you use their card for 2 pesos. from dochtor galvez a minibus runs to the point where autopista and carretera split. you can take another minibus to the toll gate (caseta de cobro) de la autopista.

From metro station "Indios verdes" take a minibus to autopista, or toll gate.