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Antofagasta is a very long and skinny city, stretching north to south. Truck drivers going to Mejillones from the south will drive through the city instead of via the bypass, so they are actually your best bet on being dropped off somewhere central. If you didn't discuss with your driver where exactly they are going and if it's central, you might have to walk 12 km to where you need to be. Make sure you're on the same page.

Thanks to mostly Colombian immigrants and contrary to what most Chileans seem to think, there is lots of cheap-ish delicious food in Antofagasta!