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There are borders with [[Costa Rica]] in the North and [[Colombia]] in the South. However, there are no roads to [[Colombia]]. There is a way to go through the jungle but it's extremely dangerous due to the Colombian 'guerillas'.
It is possible to hitchhike a boat from Panama to Colombia or [[Ecuador]] so you don't have to cross the [[Darien Darién Gap]]. On the Caribbean coast you may find boats in [[Bocas del Toro]], right on the canal or in [[Portobello]].
In Portobello you should be able to jump on a charter boad to [[Cartagena]], Colombia (~325 US).