Debrecen is the second largest city in Hungary. <map lat='47.53111102290634' lng='21.627273559570312' zoom='11' view='0' float='right' />
Walk out of the city centre along the street Szoboszlói út until the intersection with István utca (about 2.6 km from the central square). Hitch after the intersection, at the exit of the Penny Market parking lot, in front of the sign marking the Debrecen city limits. You can hitch at the entrance to the Motorway, but stopping is better at the named location. Bear in mind that the 2nd Motorway entrance has better stopping possibilites but much less traffic.
Note that on weekends there is little long-distance traffic here, only people going to nearby villages (where you could easily get stuck). If you are hitchhiking on a Saturday or Sunday, it will be much faster and safer to hitchhike south from Debrecen to Berettyoujfalu and then turn west towards Budapest.
Christopher Culver got a lift out of Debrecen by taking a long walk north on Böszörményi út until the end of the city. This is national road 35. Just before a road curves off to the east to join the M5/E79, there is a traffic light. You can hold out a sign for Miskolc and try to attract one of the drivers stopped at the light. Not the best place, but it worked.
It may be considerably easier to simply take a bus to Józsa, the first village north of Debrecen on this road. You can then stop a car going all the way to Miskolc much more easily.
If your destination is Košice in Slovakia, it is best to ask your driver to let you out outside of Miskolc at the junction near Felsõzsolca.
South towards Berettyóújfalu, Szeged 47
200 m east of the train station, there is a large junction. Walk up onto the overpass. This road is Mikeperci út, which is the start of the E79. Walk south a couple of kilometres, past the airport, until the MyBox shopping centre. Here after a stoplight you can stop cars leaving the city.
East towards Romania 48
National road 48 is a minor route to Romania. For most points in Transylvania, it is faster to go to Berettyóújfalu and then enter Romania at Oradea.