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Take the bus #27 from the centre the the final s top ''Platia Stavroupolis'' (Stavroupolis square). Then take bus #85 and you're already on your way. Almost any stop of this bus leaves you at a good hitchhiking point, but the nineteenth stop ''21o chiliometro'' (21st kilometre) is right on a petrol station on the way to Serres and the Bulgarian border (to Sandansky, Blagoevgrad, Sofia). The road is E79 and it's not a motorway, especially after the border. These city bus tickets cost only 50 cents (that you don't even have to pay) and take you quite some kilometres out of the city towards all destinations.
=== North West to [[Kilkis]] ([[Greece]]) or [[Macedonia]] ===
Basically you need to take 2 buses. Very similar to the above direction to Sofia. But this time it is bus #27 / #27a and bus #84 / # 84a. You can change buses in two different places.
* This way is faster as you don't need to stay on bus #27 so long. Take bus #27 or #27a and get off at Minerva stop in Oreokastrou suburb. If you walk some hundreds of meters from the bus stop where you get off, in the direction the bus was going, you will reach a crossroads and on your left you will see another bus stop. From there you can take bus #84.
* This way is easier because you don't need to change bus stops, it is the way mentioned in the Northeast to Sofia section. Take the bus #27 or #27a from the centre the the final s top ''Platia Stavroupolis'' (Stavroupolis square). Then at the same place take bus #84 / #84a and you're already on your way.
Stay on bus #84 whilst it passes through 2 villages, Liti and Melissochiori. When it is out of Melissochiori, at one point the bus will cross the road going to Kilkis and you will see signs for Kilkis. When you are at the cross roads you can press the stop button on the bus and it will stop just after the cross. There is a bus stop there. Then you are at a great spot for hitching a ride to Kilkis, Gallikos or even Macedonia(but not the most common way to Skopje. it is a different border).
=== North West to Serbia (Belgrade) ===