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I go quite often Prague<->Pilsen and this is the best spot for me. Take metro B (yellow line) to "Hůrka", walk around Albert shop, upstairs and over the small bridge. Than continue Walk around the school and still maintaining the same direction. You will see a wall that hides the wall road we need to take, so go behind, there it. There is a bus stop and a big road. Go right to the crossroads, there go left. You will se signs "Plzeň". Over Go over the bridge and down to the left just around the corner and there is a great place: a bus stop. Quite long and lot of space to stop. Police stopped only once but after 2 minutes talking they went out and let me there.