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Departure Santo Domingo Sunday, Tuesday and Thursday at 8 p.m., arrival in Mayaguez (Puerto Rico) 8 a.m. the next day.
Departure Mayaguez (Puerto Rico) Monday, Wednesday and Friday 8.p.m., arrival Santo Domingo 8 a.m. the next day. (www.ferriesdelcaribe.com, (809) 688 4400 for Dom. Rep.)
It's very expensive. 163 USD one-way, 391 USD roundtrip, 172-202 one-way with car. I don't know if it's hitchable, but i guess worth a try.