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Arequipa is a city in southern Peru.
North-East towards Puno, Colca Canyon, Juliaca, Cuzco
Take a bus from Av. Ejercito con Av. Cayma that goes to Yura, then jump off the bus right after the cement factory, in Yura there is a spot where all the trucks need to stop to be checked.
Alternatively, take combi n°4 (1 Sol) direction "Cono norte" until "kilòmetro 16". There, you'll be enough on the outskirts of the city to find cars who are driving long distances. The combi leaves from the corner of "Calle P.te Grau" and " Calle S. Catalina".
North towards Lima
Take a bus from Av. Independencia to Uchumayo (1 sol). Get off at Uchumayo's main square (terminus of bus route) and walk one block down an alley/stairs to a toll booth on the highway.